Patch Manager Plus server performs various tasks from installing agents on the client computers, scanning computers, downloading and deploying the patches. The antivirus that you have installed in your network would hinder the functioning of the Patch Manager Plus server and agent components. This could result in various failures during agent installation, synchronizing the patch database (for PMP on-premise), scanning the computers, downloading the patches, deploying them. So, it is always recommended to exclude all the folders related to Patch Manager Plus on the server (only for PMP on-premise)/distribution server and agent computers.
The following files located under the respective directories should be excluded from antivirus scan
On the machine where Patch Manager Plus is installed, notificationserver.exe should be added to the exceptions list
All the above mentioned files and folders are verified and signed by Zoho. Excluding them from antivirus doesn't cause any harm. Here is a sample document, to know more excluding folders from Symantec End Point, you can refer this for more details: How to add an exception to SEP?
Note: It is recommended to exclude files individually instead of grouping them under a folder and applying exception rules. This is to ensure that susceptible files don't fall under any such folders and cause harm.
If you are using a Patch Manager Plus build version below 10.0.545 then the server folder name will be PatchManagerPlus_Server.
To know more about the steps to exclude the folder from scan click here.