You cannot integrate with Tenable.sc server if the SSL certificate is not trusted. You can see the error message Certificate not trusted while configuring Tenable.sc Integration Settings.
In case Tenable.sc integration isn't available in your Patch Manager Plus server, kindly contact support.
The following steps will help in resolution:

Add each certificate using the below-mentioned procedure:
The current keystore password is changeit and avoid making any modifications to it.
The certificate trust has been successfully established. You will now be able to integrate with Tenable.sc server.
In the product console, before configuring base URL in Tenable.sc Integration Settings, ensure that the base URL of Tenable.sc's host/IP address is same as the DNS/IP address in the Subject Alternative Name field of the certificate's Details section. Also ensure the Common Name matches with the base URL in Tenable.sc's (On-Prem) Integration Settings. If the above conditions are not met, refer to Tenable's documentation for detailed instructions on regenerating certificates.

Kindly contact support for any queries.